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Jianpeng Ma(02-25-05)
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(10-28-05) Ying Xu
(10-28-05) Ying Xu
(10-28-05) Ying Xu
Regents-Georgia Research Alliance Eminent Scholar And Professor Department of Biochemistry & Molecular Biology Director, Institute of BioinformaticsTitle: Computational Prediction of Functional Modules and Their Regulatory Networks in Microbial Organisms
Abstract: In this talk, I will present our recent work on computational prediction of biological networks in microbial organisms. I will discuss a number of computational techniques that we have been developing in the past few years, including prediction of operon/regulon structures, prediction of molecular interactions, and mapping of pathways/networks across microbial genomes, identification of functional modules through comparative genome analysis, in support of our network prediction work. I will also discuss the challenging issues we are facing in terms of developing more effective computational tools and getting experimental data. I will then demonstrate how these tools have been used in support of elucidation of a few networks in cyanobacteria, including phosphorous assimilation network, carbon fixation network and nitrogen assimilation network and its crosstalk network with photosynthesis.
1. function prediction via cooccurrence, coevolution, functional-linkage(GO) 2. homolog mapping improvement via operon 3. structure-based TF relationship prediction
Yu Huang 2006-03-25
Gene Regulatory Networks Special Feature (PNAS)