University of California, Santa Cruz
David Haussler’s Howard Hughes Lab
"Dark Matter: On the Evolution and Function of Conserved Elements in the Human Genome"
What
Seminar
When
2006-01-17 16:00
2006-01-17 17:00
2006-01-17 from
16:00
to
17:00
We currently understand the function of 1.5% of the human genome's
three billion bases, primarily in the form of protein coding genes.
The recent availability of multiple vertebrate genomes has
unearthed hundreds of thousands of additional genomic regions,
constrained at levels that imply function.
While it is clear that most of these regions do not code for
protein, their sheer volume overwhelms any comprehensive
experimental approach.
Guided by preliminary measurements for few of these regions, our
lab, in collaboration with Eddy Rubin's lab at LBNL, employs a
combination of comparative and mouse transgenics approaches to
deduce the origins and functions of conserved non-coding regions.
I will describe a graph theoretic approach to obtain paralog
families of conserved regions; analyze ultraconserved elements, the
most constrained regions within the human genome, some of which
regulate key developmental genes; and track down the evolution and
multiple functions of a family of conserved elements, originating
from a "living fossil" retroposon.
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Joel Bader Seminar
Andrew Smith Seminar
Gene Regulatory Networks Special Feature (PNAS)
Abstract
three billion bases, primarily in the form of protein coding genes.
The recent availability of multiple vertebrate genomes has
unearthed hundreds of thousands of additional genomic regions,
constrained at levels that imply function.
While it is clear that most of these regions do not code for
protein, their sheer volume overwhelms any comprehensive
experimental approach.
Guided by preliminary measurements for few of these regions, our
lab, in collaboration with Eddy Rubin's lab at LBNL, employs a
combination of comparative and mouse transgenics approaches to
deduce the origins and functions of conserved non-coding regions.
I will describe a graph theoretic approach to obtain paralog
families of conserved regions; analyze ultraconserved elements, the
most constrained regions within the human genome, some of which
regulate key developmental genes; and track down the evolution and
multiple functions of a family of conserved elements, originating
from a "living fossil" retroposon.